Elastic Fibers Of The Internal Elastic Lamina Are Unraveled But Not Created With Expanding Arterial Diameter In Arteriogenesis

This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease.

Knowledge Strategy
With a better understanding of the mechanisms governing arteriogenesis, we may find pharmacological targets that could enhance collateral artery formation. This could lead to a pharmacological therapy that effectively increases blood flow to an ischemic tissue which would revolutionize management of patients with arterial occlusive diseases.

Professional Practice Gap
Patients suffering from arterial occlusive diseases would benefit tremendously if there were an effective medical therapy that could revascularize ischemic tissues. Collateral arteries develop (in a process termed arteriogenesis) as a spontaneous adaptation when a large conductance artery becomes occluded. The importance of collateral arteries for maintaining organ and limb perfusion has long been recognized, but their development is incompletely understood. If enhanced collateral artery development could be achieved thorough pharmacological means, it would offer a promising means to noninvasively enhance perfusion for these patients. 

Learning Objectives

To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients. 


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