Evaluation of A Targeted Drug Eluting Intravascular Nanotherapy To Prevent Neointimal Hyperplasia In A Novel Atherosclerotic Rat Model

This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease.

Knowledge Strategy
The results of this project, and subsequent projects it leads to, can lead to a paradigm shifting technology that can completely alter how we treat vascular diseases, improving outcomes and the overall cost of cardiovascular disease.

Professional Practice Gap
Current vascular therapies often fail from restenosis due to neointimal hyperplasia development. Drug eluting stents developed to combat this problem inhibit healing of the endothelial lining and lead to catastrophic late in-stent thrombosis and now many of these products are being cautioned against by the FDA for increasing mortality. This research is developing a new therapeutic to prevent restenosis after vascular intervention, to make these procedures safer and more durable. 

Learning Objectives

To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients. 


The opinions or views expressed on the SVS OnDemand platform and the SVS Video Library are those of the faculty and do not necessarily reflect the opinions, recommendations, or endorsement of SVS. Participants should critically appraise the information presented and are encouraged to consult appropriate resources for information surrounding any product or device mentioned. Information presented, as well as publications, technologies, products and/or services discussed, are intended to inform the learner about the knowledge, techniques, and experiences of SVS faculty who are willing to share such information with colleagues. The SVS disclaims any and all liability for damages to any individual user for all claims which may result from the use of said information, publications, technologies, products and/or services and events.

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