Pharmacological Inhibition Of Bruton's Tyrosine Kinase Attenuates Experimental Abdominal Aortic Aneurysms
This activity was presented at 2020 VRIC as part of Abstract Session 3: Aortopathies and Novel Vascular Devices.
This study demonstrated that BTK inhibitor ibrutinib, FDA-approved drug, attenuated the formation of, and further progression of established, experimental AAAs in two mechanistically distinct but complementary AAA model systems. Our results suggest that pharmacological inhibition of BTK may represent a novel translational strategy for AAA disease suppression.
Professional Practice Gap
Macrophages are critical for abdominal aortic aneurysm (AAA) pathogenesis. Bruton’s tyrosine kinase (BTK) contributes to macrophage-driven diseases s. It is not known whether BTK plays a role in AAA disease. Additionally, currently there is no approved drugs for treating aortic aneurysm disease.
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