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ForwardPharmacological Inhibition Of Bruton's Tyrosine Kinase Attenuates Experimental Abdominal Aortic Aneurysms
This activity was presented at 2020 VRIC as part of Abstract Session 3: Aortopathies and Novel Vascular Devices.
Knowledge Strategy
This study demonstrated that BTK inhibitor ibrutinib, FDA-approved drug, attenuated the formation of, and further progression of established, experimental AAAs in two mechanistically distinct but complementary AAA model systems. Our results suggest that pharmacological inhibition of BTK may represent a novel translational strategy for AAA disease suppression.
Professional Practice Gap
Macrophages are critical for abdominal aortic aneurysm (AAA) pathogenesis. Bruton’s tyrosine kinase (BTK) contributes to macrophage-driven diseases s. It is not known whether BTK plays a role in AAA disease. Additionally, currently there is no approved drugs for treating aortic aneurysm disease.
Learning Objectives
To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients.
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Price
This content is provided to members of the Society for Vascular Surgery as a member benefit. If you are not a current member of SVS click here for information on how to apply for membership.