Programmed Death Ligand-1 Regulates T-cells And M2 Macrophages to Control Wall Thickening During Arteriovenous Fistula Maturation
This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease.
PDL1 antibody increased T-helper cells and decreased Treg, consistent with increase of inflammation. Moreover, PDL1 antibody reduced vascular wall thickening during AVF maturation. These results indicate that PDL1 have a critical role to cause inflammation during AVF maturation and might be a therapeutic target to improve AVF success.
Professional Practice Gap
T-cells are essential for arteriovenous fistula (AVF) maturation, however, little is known about regulation of T-cells (Treg) during AVF maturation. Programed death ligand-1 (PDL1) can induce regulatory T-cells and reduce inflammation. We show that how PDL1 control T-cell population and AVF maturation.
To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients.
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