Title
Category
Credits
Event date
Cost
Programmed Death Ligand-1 Regulates T-cells And M2 Macrophages to Control Wall Thickening During Arteriovenous Fistula Maturation
  • Basic and Translational Research
  • Atherosclerosis Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease.Knowledge StrategyPDL1 antibody increased T-helper cells and decreased Treg, consistent with increase of inflammation. Moreover, PDL1 antibody reduced vascular wall thickening during AVF maturation. These results indicate that PDL1 have a critical role to cause inflammation during AVF maturation and might be a therapeutic target to improve AVF success.
TRPC6 Depletion Results in Loss of Myocardin And Phenotypic Modulation In Vascular Smooth Muscle Cells
  • Basic and Translational Research
  • Atherosclerosis Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease.Knowledge StrategyThis research describes a novel, TRPC6-dependent pathway that regulates vascular smooth muscle cells phenotype. The results of this study may lead to mechanism-based therapies to reduce phenotypic switching, and thus mitigate neointimal hyperplasia, following vascular intervention.
Periadventitial Delivery of Simvastatin From Microparticles Attenuates Arteriovenous Fistula Outflow Vein Neointimal Hyperplasia
  • Basic and Translational Research
  • Neo Intimal Hyperplasia
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 1: Arterial Remodeling and Discovery Science for Venous Disease. Knowledge StrategyPeriadventitial delivery of simvastatin from microparticles attenuates arteriovenous fistula outflow vein neointimal hyperplasia. It provides a new option to prevent arteriovenous fistula failure.Professional Practice GapIn the present study, there was no assembled marker on simvastatin or microparticles, which could illustrate migration or residual dose in the outflow veins. 
Absence Of Cpla2 In Lrp1 Smooth Muscle Cell Deficient Mice Promotes Severe Aortic Atherosclerotic Disease
  • Basic and Translational Research
  • Atherosclerosis Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 2: Atherosclerotic Disease and Role of the Immune System Knowledge StrategyResults from our studies will identify molecular mechanisms in the process of underpinning novel therapeutic targets for the devastating consequences of treating atherosclerotic disease plaque vulnerability and rupture by studying bioactive lipid dysregulation.
Serum Circulating Fatty Acid Synthase As A Diagnostic Biomarker For Chronic Limb-Threatening Ischemia
  • Basic and Translational Research
  • Extremity Ischemia
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 2: Atherosclerotic Disease and Role of the Immune System.Knowledge StrategyThis study showed that circulating fatty acid synthase (cFAS) is independently associated with CLTI but not DM. Future studies may explore using cFAS as biomarker for severity of PAD to guide clinical management, or as a target for development of medical therapeutics.
ZEB2 Regulates Activation And Exhaustion Programming Of CD8+ T Cells In Atherosclerosis
  • Basic and Translational Research
  • Atherosclerosis Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 2: Atherosclerotic Disease and Role of the Immune System. 
The Role Of Mast Cells In Atherosclerotic Plaque Calcification
  • Basic and Translational Research
  • Atherosclerosis Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 2: Atherosclerotic Disease and Role of the Immune System.Knowledge StrategyMast cell phenotype and secreting mediators could be detected in the plasma of patients with carotid atherosclerotic plaque and predict the clinical outcome of the patient.
Polygenic Risk Score Identifies Patients At Increased Risk For Abdominal Aortic Aneurysm And May Benefit From Ultrasound Screening
  • Basic and Translational Research
  • Aortic Aneurysm Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 2: Atherosclerotic Disease and Role of the Immune System. Knowledge StrategyThrough the use of low cost genotyping, we are able to identify a subset of the population at higher risk for AAA and who may benefit from screening beyond the current USPSTF recommendations.
Epigenetic Modifications Influence Macrophage-mediated Inflammation Inabdominal Aortic Aneurysms
  • Basic and Translational Research
  • Epigenetics in Vascular Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 3: Aortopathies and Novel Vascular Devices. Knowledge Strategy The results of this study allow us to better understand vascular inflammation driving AAA formation and potential intervene medically.Professional Practice Gap There is a lack of proven medical therapy to prevent AAA growth. This abstract demonstrates that macrophage epigenetic modifications regulate inflammation in AAAs and highlights a new mechanism to target. 
The Perfuse Dual Chamber Stent Improves Donor Organ Recovery In A Porcine Model
  • Basic and Translational Research
  • Bio Medical Engineering Research
$0.00
This activity was presented at 2020 VRIC as part of Abstract Session 3: Aortopathies and Novel Vascular Devices. Knowledge Strategy Use of a dual chamber stent to improve organ recovery and reduce ischemic injury.Professional Practice Gap Perfusion of abdominal organs during organ recovery.

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