Autophagy Remodels Mitochondria During Differentiation And Enhances Longevity Through Ulk1 Kinase Signaling Of Induced Pluripotent Stem Cell-derived Endothelial Cells

This activity was presented at 2020 VRIC as part of Abstract Session 4: Vascular Regeneration, Stem Cells, and Wound Healing.

Knowledge Strategy
This research represents a significant step in overcoming prior major limitations for patient-specific induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) regarding longevity and function in culture that have been a barrier for clinical applications. These findings open the door for future investigations into clinical applications for iPSC-ECs such as therapeutic injections for critical limb ischemia, or for engineering patient-specific bypass conduits for peripheral arterial disease.

Professional Practice Gap
To date, clinical applications for patient-specific stem cell-derived endothelial cells have been limited by poor longevity in culture and loss of mature cellular phenotype and function due to premature senescence.

Learning Objectives

To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients.


The opinions or views expressed on the SVS OnDemand platform and the SVS Video Library are those of the faculty and do not necessarily reflect the opinions, recommendations, or endorsement of SVS. Participants should critically appraise the information presented and are encouraged to consult appropriate resources for information surrounding any product or device mentioned. Information presented, as well as publications, technologies, products and/or services discussed, are intended to inform the learner about the knowledge, techniques, and experiences of SVS faculty who are willing to share such information with colleagues. The SVS disclaims any and all liability for damages to any individual user for all claims which may result from the use of said information, publications, technologies, products and/or services and events.

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