Autophagy Remodels Mitochondria During Differentiation And Enhances Longevity Through Ulk1 Kinase Signaling Of Induced Pluripotent Stem Cell-derived Endothelial Cells
This activity was presented at 2020 VRIC as part of Abstract Session 4: Vascular Regeneration, Stem Cells, and Wound Healing.
This research represents a significant step in overcoming prior major limitations for patient-specific induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) regarding longevity and function in culture that have been a barrier for clinical applications. These findings open the door for future investigations into clinical applications for iPSC-ECs such as therapeutic injections for critical limb ischemia, or for engineering patient-specific bypass conduits for peripheral arterial disease.
Professional Practice Gap
To date, clinical applications for patient-specific stem cell-derived endothelial cells have been limited by poor longevity in culture and loss of mature cellular phenotype and function due to premature senescence.
To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients.
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