Downregulation Of Inflammation And A Cascade Of Pro-angiogenic Signals Mediate The Beneficial Effects Of Gene-modified Stem Cell Therapy In Hindlimb Ischemia

This activity was presented at 2020 VRIC as part of Abstract Session 4: Vascular Regeneration, Stem Cells, and Wound Healing. 

Knowledge Strategy
We attempt to increase stem cell's inherent therapeutic potential with a novel vector to increase cell's homing capabilities and overall potency.

Professional Practice Gap
Patients with critical limb ischemia often have progressed on current medical therapies and have either failure surgical interventions or cannot undergo a surgical procedure. These no-option patients currently have no other option other than amputation, our pre-clinical study attempts to discovery new therapeutics for CLI patients in hopes of future limb salvage.

Learning Objectives

To create a virtual environment for the exchange of basic and translational vascular science that stimulates thoughtful discussion and motivates participants to discover solutions to important problems affecting vascular patients.


The opinions or views expressed on the SVS OnDemand platform and the SVS Video Library are those of the faculty and do not necessarily reflect the opinions, recommendations, or endorsement of SVS. Participants should critically appraise the information presented and are encouraged to consult appropriate resources for information surrounding any product or device mentioned. Information presented, as well as publications, technologies, products and/or services discussed, are intended to inform the learner about the knowledge, techniques, and experiences of SVS faculty who are willing to share such information with colleagues. The SVS disclaims any and all liability for damages to any individual user for all claims which may result from the use of said information, publications, technologies, products and/or services and events.

Course summary
Course opens: 
Course expires: 


Please login or register to take this course.

This content is provided to members of the Society for Vascular Surgery as a member benefit. If you are not a current member of SVS click here for information on how to apply for membership.